José Mourinho’s side are six points behind Arsenal and five ahead of Everton, meaning the outcome of this weekend’s fixture will not affect their position.
However, while missing out on the top four would ordinarily be considered a disappointment due to a failure to qualify for the Champions League, Manchester United can still reach Europe’s elite club competition.
Next Wednesday, the Red Devils take on Ajax Amsterdam in the Europa League final. Victory there would ensure a place in the 2017/18 Champions League.
With Crystal Palace having also ensured their own Premier League survival courtesy of a 4-0 win over Hull last weekend, Mourinho has suggested that he will bring several youngsters into the squad.
Here’s how our algorithm thinks Manchester United will line up this Sunday:
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Mourinho is unlikely to risk all of his most important players with such a vital European game on the near horizon. However, he will be without some not through choice, including star striker Zlatan Ibrahimović, Luke Shaw and Marcos Rojo, who are injured.
Ashley Young and Timothy Fosu-Mensah are also sidelined, while Belgium international midfielder Marouane Fellaini is suspended for the Crystal Palace clash.
Mourinho has confirmed that first-choice goalkeepers David de Gea and Sergio Romero will both be rested, and that 20-year-old Portuguese shot-stopper Joel Pereira will make his full Premier League debut.
He will likely be protected by a back line featuring Eric Bailly, Phil Jones, Chris Smalling and Matteo Darmian, while versatile 19-year-old Axel Tuanzebe continuing in midfield alongside Michael Carrick.
Up front, Wayne Rooney will be backed up my a trident of Henrikh Mkhitaryan, Juan Mata and Anthony Martial as Manchester United look to end the league season on a high note and build confidence for their meeting with Ajax.