With top spot being guaranteed, there were a number of changes for the hosts, but that didn’t stop their dominance.
We look at five things we learnt from Wembley.
Serge Aurier: Jekyll and Hyde?
There’s no doubt that Serge Aurier is a very good footballer indeed, and it was the Frenchman who was key as Tottenham made the breakthrough early on.
He bombed down the right and played a lovely ball in for Llorente to fire home.
“I think he is a top-class right-back.”
He showed his fiery side again here, and was lucky not to see red for a nasty studs-up tackle on Efstathios Aloneftis.
If he wants to establish himself s first choice right-back ahead of Kieran Trippier, that will have to be eliminated from his game.
Nkoudou justifies Pochettino faith
Speaking before the game, Pochettino bigged up N’Koudou.
“I am happy with [Nkoudou] in the last few weeks,” said the Argentine on Tuesday.
“He started to realise that he needed to improve in many things.
“He’s so young. I wanted to give him an opportunity before but maybe it was impossible. Maybe tomorrow he will have the possibility to play and to prove that he can help the team and start to grow up.
“When players are so young, always they need different timings and to realise how they need to work. I think he’s a great guy.
“There’s nothing to complain about with his behaviour and everything, because he’s a lovely kid. But in professional football… In the last few weeks he’s shown he should have the possibility to play and show his quality.”
Pochettino was true to his word, handing the winger his first start of the season.
There weren’t too many players more involved than the Frenchman, he had five shots, with three of them on target, forcing Nauzet Pérez into decent saves, before his deflected effort flew in to make it 3-0.
He completed six dribbles too, more than anyone else on the pitch.
Son deserves to be a regular starter
It’s been a very good few weeks for Son. He was named International Asian Player of the Year at the end of November, a month which his screamer against Borussia Dortmund also saw Spurs secure top spot in Group H.
The Korean also scored against Watford at the weekend, but despite that it still doesn’t feel like he’s a guaranteed starter, having com off the bench nine times already this season.
It wasn’t his best game, but he didn’t have to be at the top of his game to outclass a lacklustre APOEL side.
The 25-year-old scored the game’s second, with a step-over before a nice lay-off to Llorente, he was more alert than the Cypriot defence and curled it into the corner. It was a classy finish and once against he made his case for Pochettino to keep him off the bench.
Alongside N’Koudou, he made five shots on the pitch, three on target, the most on the pitch.
Fernando Llorente shows his worth
This was the 17th game of Llorente’s Tottenham career, and he went into the match at Wembley without a Spurs goal since his summer move from Swansea City.
Of course, most of his appearances before today were off the bench, but six hours and 59 minutes into his match action for Tottenham, he finally scored his first goal for the club.
The cross came in from Aurier after a lovely ball wide by Harry Winks, and the Spaniard turned well to finish coolly.
The 32-year-old was a focal point for Pochettino’s side up front and showed what he can offer, although of course that was known by most people who saw him at Swansea last season.
He was always a threat from corners, and played an important role in defending set pieces too.
Llorente did have a disappointing moment though, he could have made it two in the second half , but instead missed the ball when his standing foot gave way.
If Tottenham want another option from Harry Kane, he will definitely offer that, and he could even play alongside the Englishman, as he showed earlier on in the Champions League against Real Madrid.
Sterner challenges will lie ahead than APOEL
To finish ahead of the likes of Real Madrid and Borussia Dortmund was a great achievement for Tottenham, but today felt like a training exercise.
Juan Foyth on his Champions League debut wasn’t tested by Mickaël Poté up front.
The Cypriot team haven’t made it to the Europa League and based on this, it’s no real loss.