Two goals in the space of three minutes saw them pick up a win away to Real Sociedad on Saturday in La Liga, and they will want to get off to the best possible start in a tricky Champions League group containing, Tottenham Hotspur and Inter Milan.
One of the pre-tournament favourites, Barca will be confident of picking up all three points in this opening fixture.
Our unique algorithm has predicted the Barcelona side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, and the statistical likelihood of a player being selected. The widget can also show you players’ recent form and stats.