Currently eighth in the top flight, the Foxes have taken 26 points from 18 games this season. United, meanwhile, are in 2nd place after claiming 14 points from their 18 matches.
José Mourinho will be keen to put their Carabao Cup upset to Bristol City behind them with a win, but this is typically the type of fixture where they struggle.
Our unique algorithm has predicted the Leicester side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, the statistical likelihood of a player being selected, the competition the match is in, players’ previous performances and the opponent’s style.
And you can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick your ideal XI for the game.You can also see each player’s stats once you’ve selected them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.