Currently 12th in the top flight, the Saints have taken 18 points from 22 games this season despite struggling for goals for much of the campaign.
Huddersfield, meanwhile, are in 11th place after claiming 21 points from their 18 matches. The Terriers have struggled on the road for much of this season, but did thrash Watford 4-1 at Vicarage Road last weekend.
Our unique algorithm has predicted the Southampton side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, the statistical likelihood of a player being selected, the competition the match is in, players’ previous performances and the opponent’s style.
And you can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick your ideal XI for the game.You can also see each player’s stats once you’ve selected them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.