Coach Óscar Tabárez has taken charge of more matches with La Celeste than any international coach has with a single nation previously and will look for a repeat of the 2010 tournament when Uruguay finished fourth in South Africa.
Our unique algorithm has predicted the Uruguay side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, the statistical likelihood of a player being selected, the competition the match is in, players’ previous performances and the opponent’s style.
And you can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick your ideal XI for the game. You can also see each player’s stats once you’ve selected them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.