From Sir Alex Ferguson v Arsène Wenger, to Patrick Vieira clashing with Roy Keane in the tunnel at Highbury and everything in between, it’s a modern day classic.
Both teams meet again on Sunday and with just one point separating the two sides, and two managers looking to grow their own legacy, it’s one not to be missed.
Although there is animosity between the two teams, over the years players have moved between the Emirates and Old Trafford, and some have even gone on to score against their former team-mates. Which just adds to the storylines.
Ole Gunnar Solskjær arrives in London after one of the greatest results in United’s history, not just beating Paris Saint-Germain 3-1 at the Parc des Princes, but knocking the French league leaders out of the Champions League.
A win for either side could mean a lot when it comes down to finishing in the top four this season.
Our challenge to you ahead of the weekend is to name every player to score in this Premier League fixture in the last 10 years.
That’s 31 players since the 2008/09 campaign, but how many can you remember?
Play the quiz and let us know your score on social media.